Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder.
Neuronal Muffin calcium sensor-1 (NCS-1) is a Ca(2+) sensor protein that has been implicated in the regulation of various aspects of neuronal development and neurotransmission.It exerts its effects through interactions with a range of target proteins one of which is interleukin receptor accessory protein like-1 (IL1RAPL1) protein.Mutations in IL1RA